In a recent study, higher expression of SENP1 was found in human osteosarcoma tissue than in adjacent normal tissue (53/60 vs. 28/60) [151]; and levels of SENP1 derived from patient plasma exosomes directly correlate with osteosarcoma tumor size, location, necrosis rate, pulmonary metastasis, and surgical stage [151]. This evidence concerns the gene SENP1 and osteosarcoma.