Numerous studies have shown that TMEM166 is up-regulated and involved in tumor suppression, chemotherapeutic resistance and acute liver failure by promoting autophagy and/or apoptosis [11,13,14,15,16,19], while in the present study, TMEM166 was first up-regulated and then down-regulated in MPP+-induced oxidative stress (Figure 1J). The gene discussed is EVA1A; the disease is acute liver failure.