Taking into account that extrarenal MR is involved in pathological action in the heart and blood vessels (e.g., inflammation, vasculopathy, and endothelial dysfunction) rather than in physiological homeostasis, it could also be proposed that skin MR is responsible for the deleterious effects of ALDO in inflammation-related skin diseases and skin vascular disorders [8]. Here, NR3C2 is linked to endothelial dysfunction.