Reviewing the current research on lung cancer, we found that LINC00261 may participate in tumor progression through the following mechanisms: (1) miR-522-3p, Wnt pathway [34]; (2) miR-105/FHL1 axis [35]; (3) FOXA2, ERK pathway [36]; and (4) miR-1269a/FOXO1 axis [37]. This evidence concerns the gene FOXO1 and neoplasm.