Researchers have identified the presence of both pro-and anti-inflammatory CRP, which can be used for monitoring the extent of tissue damage associated with the pathogenesis of COVID-19 [84].In a study by McElvaney et al., it was found that severe COVID-19 patients show higher levels of IL-1β, IL-6, and sTNFR1, but lower levels of IL-10 than the patient with mildly infected COVID-19 patients [85]. This evidence concerns the gene IL1B and COVID-19.