Considering SRSF1’s known roles in HIV transcription [258] and as a mediator in C9orf72 ALS [259], this work speaks to the role of TDP-43 pathology in the deregulation of ERVs and motor neuron disease, and the involvement of potentially many other co-factors in modulating the expression and control of RTEs. This evidence concerns the gene TARDBP and motor neuron disorder.