We found that daily administration of A. muciniphila in mice lacking intestinal MyD88 did not improve survival (Figure 6C) or peritonitis scores, and the Akkermansia-treated mice had a worse incidence of developing peritonitis then the non-treated ones (Figure 6D), in mice lacking intestinal MyD88, thereby showing that A. muciniphila needs a functional intestinal epithelial MyD88 protein to exert its protective effects. Here, MYD88 is linked to peritonitis.