Recent evidence from our lab and others indicates that mitophagy proteins PINK1 and Parkin are largely reduced in AD, primarily due to abnormal interactions between Aβ and p-Tau with the fission protein Drp1 [23,24,25,26,27,28,29,30], leading to reduced clearance of dead or dying mitochondria. This evidence concerns the gene DNM1L and Alzheimer disease.