MLC1 and central nervous system cancer: The biochemical and electrophysiological characterization of MLC1-T17A and T17D mutants, demonstrated that this specific post-translational modification is essential for MLC1 to modulate the biophysical and functional properties of VRAC and to confer Ca2+ dependence to this channel, which would be otherwise insensitive to Ca2+ ions in glioma cells [52].