Their relevance in immune mediated-disease, such as MS, MS-related disorders, and autoimmune encephalitis is supported by the detection of intrathecal antibody production against ubiquitous intracellular self-protein and specific CNS antigens, including Aquaporin-4, Myelin Oligodendrocyte Glycoprotein (MOG), or N-methyl-D-aspartate receptor (NMDAR) [109,131]. Here, MOG is linked to autoimmune encephalitis.