Recent studies with herbal supplements such as bavachinin (a pan-PPAR agonist) from the glucose-lowering malaytea scurfpea herb and ginger (a PPARδ agonist) reduced obesity in obese db/db mice, and diet-induced obesity in C57BL6J mice, respectively [29,30]. Here, PPARD is linked to obesity due to melanocortin 4 receptor deficiency.