The functional impact of this colocalization is of interest, especially given that the regulation and role of p62 has been quite well studied in other neurodegenerative disease, including Alzheimer’s disease (AD) [49], Parkinson’s disease (PD) [50,51], Huntington’s disease (HD) [52], amyotrophic lateral sclerosis (ALS), spinocerebellar ataxias (SCAs) [44,53], as well as various cancers [54,55,56]. This evidence concerns the gene SQSTM1 and Alzheimer disease.