ATXN1 and Cognitive impairment: Our bulk RNA sequencing of the whole SCA1 KI mouse cortex was performed at 12 weeks, as this is considered to be an early to-intermediate stage of disease progression in SCA1 KI mice, with motor and cognitive impairments observed, as well as gliosis and nuclear inclusions, but no major cellular loss in the cerebellum [10,27,40,41].