The functional impacts of mutant ataxin-1 expression and aggregation in extra-cerebellar regions are not fully understood [23]; specifically, whether this expression results in similar or different degrees of disease progression across brain regions, as well as how this might contribute to symptoms experienced by patients, including memory decline, executive dysfunction, and cognitive impairment [4,5,6,7]. Here, ATXN1 is linked to Cognitive impairment.