In our current work, we characterized the KPC (KrasG12D/+; Trp53R172H/+; P48-Cre) and KPPC mouse models (KrasG12D/+; Trp53R172H/R172H; P48-Cre), which represent heterozygous and homozygous mutations in p53, with regard to cancer pain, reduction in well-being, neuronal remodeling and cytokine expression profile in the tumor tissue. Here, TP53 is linked to cancer.