IRF8 and hematopoietic and lymphoid cell neoplasm: While most research supports an anti-metastasis role for IRF8 in non-hematopoietic cancers, one study found that IRF8 promoted EMT-like phenomena, cell motility, and invasion in a human osteosarcoma cell line providing evidence for a possible role in the acquisition of a metastatic-like phenotype [163].