WDR45 and Encephalopathy: In static encephalopathy of childhood with neurodegeneration in adulthood (SENDA), de novo mutations of the autophagy-related gene WIPI4 (also known as WDR45) severely impair its protein expression, and they lower the autophagic activity with the aberrant accumulation of LC3-positive structures at an early stage of autophagosome formation, which directly contributes to the occurrence of encephalopathic seizures [262].