Genetic sequencing of multiple types of epilepsy patients and seizure models indicated that gene mutations in autophagy-related pathways may contribute to the occurrence of epilepsy, such as TBCK, EPG5, VSP15, etc. In addition, impaired autophagy is sufficient to induce epilepsy in rodent models, such as genetic inactivation of Atg7 in mice. The gene discussed is EPG5; the disease is epilepsy.