Since there is, to our knowledge, no data available on the impact of NET formation in SLE patients with serological signs of exposure to the SARS-CoV-2 infection and on changes in NET formation of the same patient over time, we herein examined four NET parameters: (1) the presence of cell-free DNA, (2) NE-DNA complexes, (3) MPO-DNA complexes, and (4) the activity of NE in the sera of the aforementioned Swedish SLE cohort [10]. Here, MPO is linked to systemic lupus erythematosus.