Although alcohol is primarily metabolized by alcohol dehydrogenase (ADH) to toxic acetaldehyde, it is the activation of the microsomal ethanol oxidizing system (MEOS), a secondary alcohol-metabolic pathway, that further causes cytotoxicity, organ damage, and cancer when CYP2E1 converts alcohol into acetaldehyde when ADH is saturated [17,18,19]. The gene discussed is AVP; the disease is cancer.