Meanwhile, β-glucan from S. cerevisiae ameliorated inflammation in a DSS-induced mouse model of colitis by regulating the levels of cytokines (IL-1β, IL-6, TNF-α, and IFN-γ), increasing the expression levels of tight junction proteins [33], implying that yeast culture has favorable immunomodulatory activity. The gene discussed is IFNG; the disease is colitis.