Studying IPN resistance in salmon, Moen et al. [34] identified the epithelial cadherin gene as the causative locus of resistance to this disease, while Pavelin et al. [35] described the association between inhibition of the NEDD-8 activating enzyme 1 (NAE1) and a high reduction in IPN replication. This evidence concerns the gene CDH17 and bile duct papillary neoplasm.