However, in contrast to this enhancement by IL4, there was no significant difference in the number of either Met-1 or E0771-LG tumor cells that transmigrated the endothelial barrier in response to IL4Rα−/− BMDMs compared to WT BMDMs (Met-1 cells, n = 5, p-value(IL4Rα+/−) = 0.59 and p-value (IL4Rα−/−) = 0.15; E0771-LG cells, n = 4, p-value(IL4Rα+/−) = 0.88 and p-value(IL4Rα−/−) = 0.98) (Supplemental Figure S1D). Here, IL4 is linked to neoplasm.