TGFB1 and neoplasm: TNF-α/IL-6 synergism has been reported to slightly advance TGF-β-mediated EMT [64,65], while IL-6 by itself can upregulate EMT markers like vimentin, whereas reducing the expression of E-cadherin via the JAK/STAT/Snail pathway, thus increasing the invasive potential of the tumor [66].