Although it is still too early for safe predictions and discriminations of the magnitude of the long-COVID-19 impact on the appearance and pathophysiology of solid and hematological tumors, based on the discussion on IL-6-mediated effects on B cell malignancies [131,132], one could speculate that the incidence and progression of hematological malignancies are more likely to be directly and more intensively affected by serum levels of certain cytokines that are present in the virus-induced cytokine storm and have constantly remained increased during long-COVID syndrome. The gene discussed is IL6; the disease is hematopoietic and lymphoid cell neoplasm.