A phase I study explored twice-daily administration of 100 mg vs. 200 mg of the oral JAK2/FLT3i Pacritinib in combination with 3+7 in five patients with first-line FLT3 AML (cohort A) or in combination with 10-day cycles of Decitabine in eight patients with R/R FLT3 AML (cohort B). Here, JAK2 is linked to acute myeloid leukemia.