Recently, Venkatanarayan et al. demonstrated that the deletion of ΔN isoforms of p63 or p73 resulted in metabolic reprogramming of p53-deficient cells and regression of thymic lymphomas in mice through the upregulation of islet amyloid polypeptide (IAPP), a gene that encodes for amylin [22,23]. The gene discussed is TP53; the disease is thymus lymphoma.