This was also evident when KRAS pathway mutation frequencies were interrogated in a larger MPM dataset (n = 775 patients) from the Catalogue of Somatic Mutations in c=Cancer (COSMIC; dataset available at https://cancer.sanger.ac.uk/cosmic/browse/tissue?wgs=off&sn=pleura&ss=all&hn=mesothelioma&sh=&in=t&src=tissue&all_data=n (accessed on 3 March 2022)), since this allowed analyses stratified by histologic subtype [36]. This evidence concerns the gene KRAS and cancer.