Using multiplex immunofluorescence staining in oral cancer, we have recently introduced the CD20 cluster score, which provides a measure of clusters of CD20 B cells in co-occurrence with CD4 T cells in the invasive margin (IM), and acts as a prognostic marker predicting overall survival (OS) and disease-free survival (DFS) in patients with early OSCC (HR 0.34 and 0.47, p = 0.001 and 0.019; respectively) [18]. This evidence concerns the gene CD4 and lip and oral cavity carcinoma.