EBV-positive paediatric cHL also exhibits a more cytotoxic TME with predominant Th1 polarisation, overexpression of CD8, TIA1, TBET, and granzyme B, and reduced FoxP3+ regulatory T cells (Tregs) compared with EBV-negative disease (Th2 and Th17) [92,93]. Here, GZMB is linked to classic Hodgkin lymphoma.