PDLIM7 and breast carcinoma: In a similar manner, Hultsh et al. [63] found that the lysosomes of T-47D breast cancer cells which are resistant to the cytotoxic effects of TAM treatment are more abundant, larger, and more resistant to LMP induced by lysosomotropic agents than the lysosomes in the parental T-47D cells, further supporting a role for TAM-induced autophagy and lysosome stability [63].