Studies by Vijayaraghavan et al. [72] have demonstrated that Palbociclib induces autophagy in MCF7 and T47D breast cancer cell lines, as indicated by increased MDC staining, autophagosome generation, and increased levels of LC3B-II, Atg-7, Beclin-1, BNIP3, and p62 [72]. This evidence concerns the gene BECN1 and breast cancer.