CCL5 and neoplasm: In addition, we reported that a high DDIT4 expression was related to a poor outcome in different types of cancer, the dysregulation of POLR1C gene expression is involved in tumor aggressiveness in breast cancer, while CCL5, typically associated with a poor outcome, in TNBC is associated with a major concentration of tumor-infiltrating lymphocytes (TILs) and recruitment of CD8 T-cells, CD4 activated T-cells, NK activated cells, and M1 macrophages [17,18].