Last, multiplex profiling has shown that CDH1 and TAF1 mutations, 6q loss and chr19 gain were seen more frequently in PC of gastric origin, while more aggressive PC phenotypes were emerging with increased mutations in TP53, CDH1, TAF1, KMT2C, and chromosomal instability [71]. The gene discussed is KMT2C; the disease is pachyonychia congenita.