No differences were observed in the proportion of the different clusters according to the pTNM stage of CRC (Figure S2E) or according to their CMS classification, although there was a tendency for the frequency of CD8+ TILs to increase in CMS1 immunogenic tumors in clusters 1 and 6, characterized by high IC expression (Figure S3E). The gene discussed is CD8A; the disease is colorectal carcinoma.