As shown in Figure 4C,D (representative images of an IChigh CRC and box plots), TIGIT+ and CD94+ cell numbers were significantly higher inside the tumor in the IChigh than in the IClow subgroup (medians: 1.0% vs. 0.1% TIGIT+ cells and 0.8% vs. 0.5% CD94+ cells, and 1.1% vs. 0.3%; p values 0.005 and 0.013, respectively), whereas PD-1+ cell numbers were rather low in the two subgroups, except in some MSI and two MSS CRCs. This evidence concerns the gene TIGIT and colorectal carcinoma.