The fact that these TIGIT+ TILs were significantly higher in the IChigh than the IClow subgroup in contrast to PD-1+ TILs, whose density was identical in both subgroups, supports the relevance of targeting TIGIT and PD-1 in CRC tumors displaying a TIL infiltrate rich in both of these ICs. The gene discussed is TIGIT; the disease is colorectal carcinoma.