MYC and acute lymphoblastic leukemia: To evaluate the extent to which UHRF1 regulates the c-Myc-CDK4/6-phosphoRb axis in ALL, we quantified the expression of c-Myc, CDK4, and CDK6 following a siRNA-mediated knockdown of UHRF1 in T-ALL cell lines MOLT4 and PF832 and B-ALL cell lines BALL1 and REH (Figure A3A in the Appendix A).