To determine the biological relevance of UHRF1, we performed a siRNA-mediated knockdown of UHRF1 in the T-ALL cell line MOLT4 and B-ALL cell line REH, the results of which revealed a statistically significant reduction in cell viability following the loss of UHRF1 expression in both cell lines (Figure 1C; Figure A3 in the Appendix A). The gene discussed is UHRF1; the disease is acute lymphoblastic leukemia.