Integrated miRNA and mRNA co-profiles during skeletal muscle wasting in cancer-induced cachexia showed that extracellular matrix (ECM) associated genes are post-transcriptionally regulated by miRNAs (such as miR-29a-3p) and atrophy-related transcription factors including NF-κB, STAT3 and FOXO [123]. The gene discussed is STAT3; the disease is Cachexia.