Besides its well-known anti-inflammatory effects, 5-Aminosalicylic Acid (5-ASA) may prevent CRC by interacting with specific molecular mechanisms, for instance, by inhibiting activation of the transcription of nuclear factor kB (NF-kB) [65], downregulating cyclooxygenase-2 (COX-2) and inhibiting phospholipase D activity and proliferation [66,67]. This evidence concerns the gene PTGS2 and colorectal carcinoma.