Targeting CMP-sialic acid via a specific inhibitor decreases cell-surface sialic acid and can inhibit the metastasis of colorectal cancer [214], and knockdown of the CMP-sialic acid transporter impeded the growth of melanoma tumours and suggested that hypersialylation impedes T-cell-mediated anti-tumour responses while promoting tumour-associated regulatory T cells [215]. This evidence concerns the gene SLC35A1 and neoplasm.