Contrary to this, the expression of VE-cadherin (endothelial marker) reduced in endothelial cells co-cultured with tumor cells, and the treatment of the co-culture with [Zn(PipNONO)Cl] caused an increase in the expression of endothelial marker, restoring the endothelial phenotype to a normal condition (Figure 4B,C). Here, CDH5 is linked to neoplasm.