A third MLH1-methylated case carrying only VUS was observed in a patient (ID 828, Supplementary Table S3) diagnosed at age 46 with an endometrial tumor, with loss of MLH1/PMS2 expression and a family history of endometrial, prostate and unidentified tumors (mother, father and paternal uncle, respectively, Supplementary Table S2). The gene discussed is PMS2; the disease is endometrium neoplasm.