A patient with CRC with loss of MLH1/PMS2 expression diagnosed at age 41 (ID 1196) and a family history of pancreatic tumor (father, Supplementary Table S2) was identified as carrying VUS in the MMR-related MSH3 gene (NM_002439.5:c.1777C > T p. (Arg593Trp) and a CHEK2 VUS (NM_007194.4:c.1427C > T p. (Thr476Met), Supplementary Table S3). The gene discussed is CHEK2; the disease is colorectal carcinoma.