In turn, Puglisi et al. [41] found a significant positive correlation between POSTN expression, which was localized in the nuclei of breast cancer cells, and tumor size and the expression of VEGF-A, VEGF-R1 and VEGF-R2 receptors [41], which suggests an important role of POSTN in angiogenesis of this tumor. This evidence concerns the gene FLT1 and breast cancer.