Immunization in an induced murine fibrosarcoma model with Salmonella Typhimurium with the ability to release the NY-ESO1 antigen (a protein in germ cells that is overexpressed in cancer of the lung, melanoma, esophagus, ovary, bladder and prostate) via T3SS, induced specific CD8+ and CD4+ T cell antigen-specific responses, and eliminated the tumor [133]. The gene discussed is CD4; the disease is melanoma.