TNF and neoplasm: An example of bactofection of genes encoding TAA/TSA was evaluated in recombinant Salmonella murine models that carry genes such as HPV16 L1, which encodes the human papillomavirus type 16 capsid protein, a gene encoding the MTDH/AEG1-1 protein, an oncogene associated with angiogenesis that is overexpressed in 40% of patients with breast cancer; a gene encoding the 4-1IBBL molecules, a member of the TNF family; and a CEACAM 6, a cell adhesion molecule; in all cases, they led to a decrease in tumor mass and increased survival [4].