IL18 and neoplasm: Some examples are reported in several studies that have demonstrated the release of chemokines and cytokines such as CCL21 [62]; IL-2 [44,146]; IL-4 [147]; IL-18 [148]; IL-24 [149]; IFN-γ [151]; and LIGHT, also known as a lymphotoxin [152] analogue, into the tumor microenvironment.