The breast cancer patients were classified as high-risk based on several genetic and non-genetic risk factors, including a family history of breast/ovarian cancer, the Gail model, breast cancer predisposition genes (protein-truncating variants in ATM, BRCA1, BRCA2, CHEK2, PALB2, BARD1, RAD51C, RAD51D, or TP53), and breast cancer PRS [197,198,199]. The gene discussed is PALB2; the disease is breast carcinoma.