Interestingly, the Cancer Genome Atlas (TCGA) showed that 13 genes were recurrently mutated in prostate cancer: deletions of SPOP, TP53, FOXA1, PTEN, MED12 and CDKN1B; additional clinically relevant genes were identified with lower frequencies, including BRAF, HRAS, AKT1, CTNNB1 and ATM [15]. Here, SPOP is linked to Familial prostate cancer.