Of relevance, ST2, the IL-33 receptor, was overexpressed in human CCA, and it has been demonstrated that IL-33, via IL-6, has a critical role in promoting CCA development in mice with a constitutive activation of Akt (myr-Akt) and Yap (YapS127A) [45,98,99]. This evidence concerns the gene AKT1 and cholangiocarcinoma.