Recently, it was proposed that renal CSCs isolated from renal cell carcinomas can mediate tumor growth and be the cause for resistance to standard chemo- and radiotherapies, and even tyrosine kinase receptor inhibitors, mTOR inhibitors, VEGF antibodies, cytokines, checkpoint inhibitors, etc. [55,56,57]. Here, NTRK1 is linked to hereditary clear cell renal cell carcinoma.