Moreover, other drugs and compounds such as curcumin, omega-3 polyunsaturated fatty acids as well as sorafenib have been reported to be able to downregulate EZH2 and this was critical for their anti-cancer activity, as shown for hepatoma cells, pancreatic tumor cells, and breast cancer cells, respectively [62,63,64,65]. Here, EZH2 is linked to hepatocellular carcinoma.