Interestingly, frequencies of RB1/TP53 co-mutations were also found in many types of sarcomas, such as pleomorphic liposarcoma, leiomyosarcoma, myxofibrosarcoma, etc. The overall RB1/TP53 co-mutation frequencies are significantly higher in small cell carcinoma, neuroendocrine carcinoma, and sarcomas compared to the other cancer types (Figure 2c). This evidence concerns the gene RB1 and small cell carcinoma.