When we review the frequency distribution of samples by RB1/TP53 mutation status in these 76 cancer types, we found in most of these cancer types, the number of RB1/TP53 co-mutants is much larger than the number of samples with RB1 mutation alone whereas there are many more samples with TP53 but not RB1 mutation (Figure 2b). The gene discussed is TP53; the disease is cancer.