CDC45 and hemoglobin measurement: By evaluating RNA expression data of 32 clinically annotated HB patients of a former study [15] we were able to show that high expression of MCM2, MCM5, GINS2, and CDC45 was not associated with any clinical annotation factor, such as metastasis, vascular invasion, age > 8 years, or PRETEXT 4 stage (Table 1).