ERBB4 and colon adenocarcinoma: Additionally, it has been reported that ERRB4 expression is positively associated with lymph node metastasis [50]; that ERBB4 could play a relevant role in a gene network associated with progression from colon adenocarcinoma to liver metastases [52], and that ERBB4 could be part of a pathway that enhances the invasion of CRC cells [53].