A different mechanism by which AQPs may intervene on ATO and ATRA actions on leukemic cells, is related to isomerase Pin1, a controller of oncogenic signaling, which is activated in several tumors and is able to stimulate about 43 oncoproteins, disables more than 20 tumor suppressors, operating as a post-phosphorylation controller of oncogenic networks [84,85,86,87,88]. The gene discussed is PIN1; the disease is neoplasm.