The downstream target gene of miRNA-188-5p, DAXX, a death domain-associated protein, is a multifunctional protein that has been implicated in pro-apoptosis, anti-apoptosis, and transcriptional regulation processes [42]; acts as a tumor suppressor in osteosarcoma by mediating the deposition of histone H3.3 [43]; and is involved in pancreatic neuroendocrine tumors [44] and glioblastoma multiforme [45], as its mutation corresponds to the presence of alternative lengthening of telomeres. This evidence concerns the gene DAXX and osteosarcoma.