To further explore the relationship among ERK1/2, p-ERK, and circRNA-0044301, we investigated the expression of ERK1/2, p-ERK, and circRNA-0044301 in four pairs of GC tissue samples, namely #1, #2, #3, and #4, finding that the expression of ERK1/2 and p-ERK proteins was downregulated in all patients. This evidence concerns the gene MAPK3 and gastric cancer.