Highly aberrant lncRNAs detected in our RB sEVs OXCT1-AS1, HPYR1, HDAC2-AS2, LINC02499, slc8a1-as1, ZFAND2A-DT, LINC01359, SCOC-AS1 have not yet been reported in RB. Here, ZFAND2A is linked to retinoblastoma.