The known role of CK1α on Wnt/β-catenin signaling regulation in different cells type [22,38] and the fundamental role of β-catenin on osteoblastogenesis through the regulation of RUNX2 [19,39,40] prompted us to explore whether CK1α could modulate the osteoblastogenic potential of stromal cells through the regulation of the Wnt/β/catenin/RUNX2 axis in different CK1α loss-of-function cell models of the MM BM microenvironment, including an analysis of MM plasma cells and stromal cells. The gene discussed is CSNK1A1; the disease is Miyoshi myopathy.