Our data suggest that protein kinase CK1α is a key regulator of MM pathophysiology, since not only does it support the survival of malignant PCs through the regulation of pro-survival signaling cascades, such as β-catenin and AKT [23], but it also sustains their cross-talk with the microenvironment. The gene discussed is CSNK1A1; the disease is Miyoshi myopathy.