Additionally, a high CAF score in thyroid cancer patients was shown to be positively correlated with an increased expression of immune checkpoint markers, such as CD274, PDCD1LG2, CD86, CD80 and CTLA4, and an increased expression of markers of activated tumor-associated macrophages, including EMR1, CSF1R, CD163 and ITGM in DDTCs and PTCs. This evidence concerns the gene CTLA4 and thyroid gland carcinoma.