Interestingly, by using an in vitro model of the thyroid TME, obtained through co-culture experiments, Donadio’s group demonstrated that EVs obtained from co-cultures of thyroid cancer cells and fibroblasts promote the secretion of pro-MMP-2 and the expression of the active form MMP-2 in normal fibroblasts. The gene discussed is MMP2; the disease is thyroid gland carcinoma.