Additionally, a high CAF score in thyroid cancer patients was shown to be positively correlated with an increased expression of immune checkpoint markers, such as CD274, PDCD1LG2, CD86, CD80 and CTLA4, and an increased expression of markers of activated tumor-associated macrophages, including EMR1, CSF1R, CD163 and ITGM in DDTCs and PTCs. The gene discussed is CTLA4; the disease is thyroid cancer.